The details of FoldDB ID: fd0274 |
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| Identification | |
|---|---|
| FoldDB ID | fd0274 |
| Smiles | |
| Inchi Key | IVSSHWMBJINVKX-DEWIOZBCSA-N |
| Molecular weight | 909.991 |
| Molecular formula | C44H59N7O14 |
| Other Name
Since there is no uniform representation for the non-natural peptides. This is the name as it is mentioned in the original article and/or the external database. | Cbz-NOAla-NOPhe-NOPhe-NOIle-NOAla-NOLeu-NH2 |
| External ID | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reaxys ID | 30691933 | ||||||||
| Structural Information | |
|---|---|
| Structure reported | no |
| Other information | |
|---|---|
| Application | Anticancer Foldamers |
| Foldamer type | β Peptide |
| Other type | α‐Aminoxy peptide |
| Calculated properties | |
|---|---|
| LogP | 5.75200 |
| Rotatable Bonds | 35 |
| H Bond Donor | 7 |
| H Bond Acceptor | 9 |
| Polar Surface Area (PSA) | 282.30000 |
| Activity |
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| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0035 | MTT cell viability assay | Kyse510 | 40.2±0.8 | μM | IC50 | ||||
| fdact0036 | MTT cell viability assay | A2780 | 52.4±1.2 | μM | IC50 | ||||
| fdact0037 | MTT cell viability assay | A2780 CisR | 55±2.5 | μM | IC50 | ||||
| fdact0038 | MTT cell viability assay | HEK293 | 60.9±1.5 | μM | IC50 | ||||
| fdact0039 | MTT cell viability assay | Kyse510 | 84±2.8 | μM | IC50 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
α-Aminoxy Oligopeptides: Synthesis, Secondary Structure, and Cytotoxicity of a New Class of Anticancer Foldamers | 2016 | Diedrich D., Moita A.J.R., Rüther A., Frieg B., Reiss G.J., Hoeppner A., Kurz T., Gohlke H., Lüdeke S., Kassack M.U., Hansen F.K. | Chemistry - A European Journal | ||
