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The details of FoldDB ID: fd0317
Chemical diagram
molecule
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Identification
FoldDB ID

fd0317

One Letter code Help Icon Since there is no uniform representation for the non-natural peptides. The one letter code reported here is as it is mentioned in the original article and/or the external database.

PKIIQSVGISNL

Three Letter code Help Icon Since there is no uniform representation for the non-natural peptides. The three letter code reported here is as it is mentioned in the original article and/or the external database.

Pro-Lys-Ile-Ile-Gln-Ser-Val-Gly-Ile-Ser-Asn-Nle

External ID
Reaxys ID

32389743

Structural Information
Structure reported

no

Other information
Application

Anti-leishmanial activity

Foldamer type

α Peptide

Activity
Activity ID Assay name Cell line Target Protein Organism Assay Category Value Unit Type Measurement object
fdact0098

Trypanothione reductase [Leishmania infantum]

Leishmania infantum

In Vitro (Efficacy)

0.82

μM

IC50

fdact0099

Trypanothione reductase [Leishmania infantum]

Leishmania infantum

In Vitro (Efficacy)

4.21

μM

IC50

Citations
ID Title Year Authors Journal DOI

fdart0038

Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides

2017

de Lucio H., Gamo A.M., Ruiz-Santaquiteria M., de Castro S., Sánchez-Murcia P.A., Toro M.A., Gutiérrez K.J., Gago F., Jiménez-Ruiz A., Camarasa M.-J., Velázquez S.

European Journal of Medicinal Chemistry

..