The details of FoldDB ID: fd0318 |
|---|
Use the buttons at the bottom of Jsmol viewer to see different representations, ON/OFF Hydrogens, and ON/OFF rotation.
3D model is for representation purpose only. To access the experimental 3D structure kindly go to the browse structure tab and look for PDB or CCDC id.
.
.
| Identification | |
|---|---|
| FoldDB ID | fd0318 |
| One Letter code
Since there is no uniform representation for the non-natural peptides. The one letter code reported here is as it is mentioned in the original article and/or the external database. | PKIIQSVGI |
| Three Letter code
Since there is no uniform representation for the non-natural peptides. The three letter code reported here is as it is mentioned in the original article and/or the external database. | Pro-Lys-Ile-Ile-Gln-Ser-Val-Gly-Ile |
| External ID | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reaxys ID | 27228603 | ||||||||
| Structural Information | |
|---|---|
| Structure reported | no |
| Other information | |
|---|---|
| Application | Anti-leishmanial activity |
| Foldamer type | α Peptide |
| Activity |
|---|
| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0061 | Trypanothione reductase [Leishmania infantum] | Leishmania infantum | In Vitro (Efficacy) | 3.59 | μM | IC50 | |||
| fdact0062 | Trypanothione reductase [Leishmania infantum] | Leishmania infantum | In Vitro (Efficacy) | 15.74 | μM | IC50 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides | 2017 | de Lucio H., Gamo A.M., Ruiz-Santaquiteria M., de Castro S., Sánchez-Murcia P.A., Toro M.A., Gutiérrez K.J., Gago F., Jiménez-Ruiz A., Camarasa M.-J., Velázquez S. | European Journal of Medicinal Chemistry | ||
