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The details of FoldDB ID: fd0327
Chemical diagram
molecule
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Identification
FoldDB ID

fd0327

One Letter code Help Icon Since there is no uniform representation for the non-natural peptides. The one letter code reported here is as it is mentioned in the original article and/or the external database.

PKIβ3IQSVβ3AISNLβ3KNL

Three Letter code Help Icon Since there is no uniform representation for the non-natural peptides. The three letter code reported here is as it is mentioned in the original article and/or the external database.

Ac-Pro-Lys-Ile-β3Ile-Gln-Ser-Val-β3Ala-Ile-Ser-Nle-β3Lys-Nle-NH2

Source

synthetic construct

External ID
Reaxys ID

32389736

Structural Information
Structure reported

no

Other information
Application

Anti-leishmanial activity

Foldamer type

α/β Peptide

Activity
Activity ID Assay name Cell line Target Protein Organism Assay Category Value Unit Type Measurement object
fdact0086

Trypanothione reductase [Leishmania infantum]

Leishmania infantum

In Vitro (Efficacy)

5.38

μM

IC50

fdact0087

Trypanothione reductase [Leishmania infantum]

Leishmania infantum

In Vitro (Efficacy)

13.75

μM

IC50

Citations
ID Title Year Authors Journal DOI

fdart0038

Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides

2017

de Lucio H., Gamo A.M., Ruiz-Santaquiteria M., de Castro S., Sánchez-Murcia P.A., Toro M.A., Gutiérrez K.J., Gago F., Jiménez-Ruiz A., Camarasa M.-J., Velázquez S.

European Journal of Medicinal Chemistry

..