The details of FoldDB ID: fd0674 |
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| Identification | |||||||||
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| FoldDB ID | fd0674 | ||||||||
| One Letter code
Since there is no uniform representation for the non-natural peptides. The one letter code reported here is as it is mentioned in the original article and/or the external database. | βVEβPNCDIHV[nL]βWEWECFZRβL-NH2 | ||||||||
| Note | nL=norleucine | ||||||||
| Other note | Z=3-amino-4-carboxypyrrolidin-1-ium, βX=Beta amino acid, disulfide link between the two Cys residues | ||||||||
| Source | synthetic construct | ||||||||
| Structural Information | |
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| Structure reported | No |
| Other information | |
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| Application | VEGF (Vascular Endothelial Growth Factor) signaling inhibitor |
| Foldamer type | α/β Peptide |
| Activity |
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| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0797 | competitive FP assay | In Vitro (Efficacy) | 4.6 | µM | Ki | ||||
| fdact0798 | Pharmacokinetic | 300 | min | half life time |
| Citations | |||||
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| ID | Title | Year | Authors | Journal | DOI |
Extending Foldamer Design beyond α-Helix Mimicry: α/β-Peptide Inhibitors of Vascular Endothelial Growth Factor Signaling | 2012 | Haase, Holly S., Peterson-Kaufman, Kimberly J., Lan Levengood, Sheeny K., Checco, James W., Murphy, William L., Gellman, Samuel H. | Journal of the American Chemical Society | ||
