The details of FoldDB ID: fd1106 |
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Identification | |
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FoldDB ID | fd1106 |
Smiles | |
Inchi Key | MCCMTFJDVDYCLY-MUSQQMQQSA-N |
Molecular weight | 1255.61 |
Molecular formula | C62H106N14O13 |
Source | synthetic construct |
External ID | |
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Reaxys ID | 10760594 |
Other information | |
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Application | Antagonists of BH3 Domain/Bcl-xLÂ Recognition |
Foldamer type | α/β Peptide |
Calculated properties | |
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LogP | 2.55600 |
H Bond Donor | 15 |
H Bond Acceptor | 27 |
Polar Surface Area (PSA) | 407.48000 |
Activity |
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Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
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fdact0728 | Fluorescence polarization assay | BakBH3/Bcl-xL | In Vitro (Efficacy) | 1000 | µM | IC50 |
Citations | |||||
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ID | Title | Year | Authors | Journal | DOI |
(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions | 2007 | Sadowsky, Jack D., Fairlie, W. Douglas., Hadley, Erik B., Lee, Hee-Seung., Umezawa, Naoki., Nikolovska-Coleska, Zaneta., Wang, Shaomeng., Huang, David C. S., Tomita, York., Gellman, Samuel H. | Journal of the American Chemical Society |