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The details of FoldDB ID: fd1106
Chemical diagram
molecule
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Identification
FoldDB ID

fd1106

Smiles
Inchi Key

MCCMTFJDVDYCLY-MUSQQMQQSA-N

Molecular weight

1255.61

Molecular formula

C62H106N14O13

Source

synthetic construct

External ID
Reaxys ID

10760594

Other information
Application

Antagonists of BH3 Domain/Bcl-xL Recognition

Foldamer type

α/β Peptide

Calculated properties
LogP

2.55600

H Bond Donor

15

H Bond Acceptor

27

Polar Surface Area (PSA)

407.48000

Activity
Activity ID Assay name Cell line Target Protein Organism Assay Category Value Unit Type Measurement object
fdact0728

Fluorescence polarization assay

BakBH3/Bcl-xL

In Vitro (Efficacy)

1000

µM

IC50

Citations
ID Title Year Authors Journal DOI

fdart0145

(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions

2007

Sadowsky, Jack D., Fairlie, W. Douglas., Hadley, Erik B., Lee, Hee-Seung., Umezawa, Naoki., Nikolovska-Coleska, Zaneta., Wang, Shaomeng., Huang, David C. S., Tomita, York., Gellman, Samuel H.

Journal of the American Chemical Society

..