The details of FoldDB ID: fd1107 |
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| Identification | |
|---|---|
| FoldDB ID | fd1107 |
| Smiles | |
| Inchi Key | WEROBFNMUCICFX-ZIBATQCESA-N |
| Molecular weight | 1296.66 |
| Molecular formula | C68H105N13O12 |
| Source | synthetic construct |
| External ID | |
|---|---|
| Reaxys ID | 10760993 |
| Other information | |
|---|---|
| Application | Antagonists of BH3 Domain/Bcl-xLÂ Recognition |
| Foldamer type | α/β Peptide |
| Calculated properties | |
|---|---|
| LogP | 4.44000 |
| H Bond Donor | 14 |
| H Bond Acceptor | 25 |
| Polar Surface Area (PSA) | 392.37000 |
| Activity |
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| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0729 | Fluorescence polarization assay | BakBH3/Bcl-xL | In Vitro (Efficacy) | 1000 | µM | IC50 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions | 2007 | Sadowsky, Jack D., Fairlie, W. Douglas., Hadley, Erik B., Lee, Hee-Seung., Umezawa, Naoki., Nikolovska-Coleska, Zaneta., Wang, Shaomeng., Huang, David C. S., Tomita, York., Gellman, Samuel H. | Journal of the American Chemical Society | ||
