The details of FoldDB ID: fd1111 |
|---|
Use the buttons at the bottom of Jsmol viewer to see different representations, ON/OFF Hydrogens, and ON/OFF rotation.
3D model is for representation purpose only. To access the experimental 3D structure kindly go to the browse structure tab and look for PDB or CCDC id.
.
.
| Identification | |
|---|---|
| FoldDB ID | fd1111 |
| Three Letter code
Since there is no uniform representation for the non-natural peptides. The three letter code reported here is as it is mentioned in the original article and/or the external database. | Ac-APC-Leu-β3hAla-Arg-ACPC-Leu-ACPC-Ile-β3hNle-Gly-Asp-Ala-Phe-Asn-Arg-NH2 |
| Other Name
Since there is no uniform representation for the non-natural peptides. This is the name as it is mentioned in the original article and/or the external database. | Ac-((3S,4R)-3-aminopyrrolidine-4-carboxylic acid)-Leu-beta3hAla-Arg-((1S,2S)-2-aminocyclopentanecarboxylic acid)-Leu-((1S,2S)-2-aminocyclopentanecarboxylic acid)-Ile-beta3hNle-Gly-Asp-Ala-Phe-Asn-Arg-NH2 |
| Other note | ACPC = trans-(1S,2S)-2-aminocyclopentanecarboxylic acid; APC = trans-(3S,4R)-3-aminopyrrolidine-4-carboxylic acid; hNle = (S)-homonorleucine; hAla = (S)-homoalanine. |
| Source | synthetic construct |
| External ID | |
|---|---|
| Reaxys ID | 10770794 |
| Other information | |
|---|---|
| Application | Antagonists of BH3 Domain/Bcl-xLÂ Recognition |
| Foldamer type | α/β Peptide |
| Activity |
|---|
| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0733 | Protein binding Bioassay | Bcl-xL protein | In Vitro (Efficacy) | 0.75 | µM | IC50 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions | 2007 | Sadowsky, Jack D., Fairlie, W. Douglas., Hadley, Erik B., Lee, Hee-Seung., Umezawa, Naoki., Nikolovska-Coleska, Zaneta., Wang, Shaomeng., Huang, David C. S., Tomita, York., Gellman, Samuel H. | Journal of the American Chemical Society | ||
