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The details of FoldDB ID: fd1116
Chemical diagram
molecule

Please see the original reference for structure
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Identification
FoldDB ID

fd1116

Three Letter code Help Icon Since there is no uniform representation for the non-natural peptides. The three letter code reported here is as it is mentioned in the original article and/or the external database.

Ac-APC-Leu-ACPC-Arg-ACPC-Leu-ACPC-Ala-β3hNle-Gly-Asp-Ala-Phe-Asn-Arg-NH2

Other Name Help Icon Since there is no uniform representation for the non-natural peptides. This is the name as it is mentioned in the original article and/or the external database.

Ac-((3S,4R)-3-aminopyrrolidine-4-carboxylic acid)-Leu-((1S,2S)-2-aminocyclopentanecarboxylic acid)-Arg-((1S,2S)-2-aminocyclopentanecarboxylic acid)-Leu-((1S,2S)-2-aminocyclopentanecarboxylic acid)-Ala-beta3hNle-Gly-Asp-Ala-Phe-Asn-Arg-NH2

Other note

ACPC = trans-(1S,2S)-2-aminocyclopentanecarboxylic acid; APC = trans-(3S,4R)-3-aminopyrrolidine-4-carboxylic acid; hNle = (S)-homonorleucine; hAla = (S)-homoalanine.

Source

synthetic construct

External ID
Reaxys ID

10770799

Other information
Application

Antagonists of BH3 Domain/Bcl-xL Recognition

Foldamer type

α/β Peptide

Activity
Activity ID Assay name Cell line Target Protein Organism Assay Category Value Unit Type Measurement object
fdact0738

Protein binding Bioassay

Bcl-xL protein

In Vitro (Efficacy)

0.13

µM

IC50

Citations
ID Title Year Authors Journal DOI

fdart0145

(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions

2007

Sadowsky, Jack D., Fairlie, W. Douglas., Hadley, Erik B., Lee, Hee-Seung., Umezawa, Naoki., Nikolovska-Coleska, Zaneta., Wang, Shaomeng., Huang, David C. S., Tomita, York., Gellman, Samuel H.

Journal of the American Chemical Society

..