The details of FoldDB ID: fd1135 |
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| Identification | |
|---|---|
| FoldDB ID | fd1135 |
| Other Name
Since there is no uniform representation for the non-natural peptides. This is the name as it is mentioned in the original article and/or the external database. | Ac-((3S,4R)-3-aminopyrrolidine-4-carboxylic acid)-Ala-((1S,2S)-2-aminocyclopentanecarboxylic acid)-Arg-((1S,2S)-2-aminocyclopentanecarboxylic acid)-Leu-((1S,2S)-2-aminocyclopentanecarboxylic acid)-Lys-beta3hLeu-Gly-Asp-Ala-Phe-Asn-Arg-NH2 |
| Source | synthetic construct |
| External ID | |
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| Reaxys ID | 10770818 |
| Other information | |
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| Application | Antagonists of BH3 Domain/Bcl-xLÂ Recognition |
| Foldamer type | α/β Peptide |
| Activity |
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| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0757 | Protein binding Bioassay | Bcl-2 protein | In Vitro (Efficacy) | 0.85 | µM | IC50 | |||
| fdact0758 | Protein binding Bioassay | Bcl-w protein | In Vitro (Efficacy) | 0.041 | µM | IC50 | |||
| fdact0759 | Protein binding Bioassay | Bcl-xL protein | In Vitro (Efficacy) | 0.029 | µM | IC50 | |||
| fdact0760 | Protein binding Bioassay | Bcl-xL protein | In Vitro (Efficacy) | 0.018 | µM | IC50 | |||
| fdact0761 | Protein binding Bioassay | Mcl-1 protein | In Vitro (Efficacy) | nd | qualitative | ||||
| fdact0762 | cytochrome C release | In Vitro (Efficacy) | nd | qualitative | |||||
| fdact0763 | cytochrome C release | In Vitro (Efficacy) | nd | qualitative | |||||
| fdact0764 | cytochrome C release | In Vitro (Efficacy) | nd | qualitative |
| Citations | |||||
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| ID | Title | Year | Authors | Journal | DOI |
(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition:  Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions | 2007 | Sadowsky, Jack D., Fairlie, W. Douglas., Hadley, Erik B., Lee, Hee-Seung., Umezawa, Naoki., Nikolovska-Coleska, Zaneta., Wang, Shaomeng., Huang, David C. S., Tomita, York., Gellman, Samuel H. | Journal of the American Chemical Society | ||
