The details of FoldDB ID: fd1137 |
---|
3D model is for representation purpose only. To access the experimental 3D structure kindly go to the browse structure tab and look for PDB or CCDC id.
.
.
Identification | |
---|---|
FoldDB ID | fd1137 |
Smiles | |
Inchi Key | RVPUDZDGFRFENN-GZOQNBBBSA-N |
Molecular weight | 1716.1 |
Molecular formula | C82H134N22O18 |
Source | synthetic construct |
External ID | |
---|---|
Reaxys ID | 10238838 |
Other information | |
---|---|
Application | Antagonists of BH3 Domain/Bcl-xLÂ Recognition |
Foldamer type | α/β Peptide |
Calculated properties | |
---|---|
LogP | 0.30400 |
H Bond Donor | 23 |
H Bond Acceptor | 40 |
Polar Surface Area (PSA) | 628.87000 |
Activity |
---|
Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
---|---|---|---|---|---|---|---|---|---|
fdact0766 | Protein binding Bioassay | BCL-Xl | In Vitro (Efficacy) | 1.5 | µM | Ki | |||
fdact0767 | Protein binding Bioassay | BCL-Xl | In Vitro (Efficacy) | 40 | µM | IC50 |
Citations | |||||
---|---|---|---|---|---|
ID | Title | Year | Authors | Journal | DOI |
Chimeric (α/β + α)-Peptide Ligands for the BH3-Recognition Cleft of Bcl-xL:  Critical Role of the Molecular Scaffold in Protein Surface Recognition | 2005 | Sadowsky, Jack D., Schmitt, Margaret A., Lee, Hee-Seung., Umezawa, Naoki., Wang, Shaomeng., Tomita, York., Gellman, Samuel H. | Journal of the American Chemical Society |